COVID-19 DIAGNOSIS: MOST ACCURATE TEST? RT-PCR / ANTIBODY DETECTION TEST?
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Hi. If you have cough or fever (either low grade or a high grade), with breathing discomfort or any other symptoms, then the only way to find out whether you have COVID-19 or not is to get tested.
In response to the growing COVID-19 pandemic, multiple diagnostic test manufacturers have developed and begun selling rapid and easy-to-use devices.
However, before these tests can be recommended, they must be validated in the appropriate populations and settings. Inadequate tests may miss patients with active infection or falsely categorize patients as having the disease when they do not, further hampering disease control efforts.
Now the question arises, which test to get it done??
Listen to this video till the end to find out about the different kinds of tests available, which diagnostic test is best and how each kind of diagnostic plays a role in the fight against COVID-19.
Disclaimer: Information provided by INTELLECT MEDICOS is not meant to substitute for medical advise by any physician, or experienced health care professional. Always seek advise from your physician about the clinical condition and usage of particular treatment or therapy.
REFERENCES:
1. Liu Y, Liu Y, Diao B, Ren Feifei, et al. Diagnostic indexes of a rapid IgG/IgM combined antibody test for SARS-CoV-2. medxriv [Internet]. 2020;
2. Zhang P, Gao Q, Wang T, Ke Y, et al. Evaluation of recombinant nucleocapsid and spice protein serological diagnosis of novel coronavirus disease 2019 (COVID-19). medxriv [Internet]. 2020;
3. Pan Y, Li X, Yang G, Fan J, et al. Serological immunochromatographic approach in diagnosis with SARS-CoV-2 infected COVID-19 patients. medxriv [Internet]. 2020;
5. Li Z, Yi Y, Luo X, Xion N, et al. Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis. Journal of medical virology. https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25727
6. Zhao J, Yuan Q, Wang H, Liu W, Liao X, Su Y, et al. Antibody responses to SARS-CoV-2 in patients of novel coronavirus disease 2019. medxriv [Internet]. 2020;
7. Okba N.M.A, Muller M.A., Li W, Wang C, et al. SARS-COV-2 specific antibody responses in COVID-19 patients. medxriv [Internet]. 2020
8. Gorse GJ, Donovan MM, Patel GB. Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies identifying coronavirus-associated illnesses. Journal of medical virology. https://doi.org/10.1002/jmv.25715
9. Lin D, Liu L, Zhang M, Hu Y, et al. Evaluation of serological tests in the diagnosis of 2019 novel coronavirus (SARS-CoV-2) infections during the COVID-19 outbreak. medxriv [Internet]. 2020;
10. Wölfel R, Corman V, Guggemos W, Seilmaier M, Mueller M, Niemeyer D, et al. Virological assessment of hospitalized patients with COVID-2019. Nature [Internet]. 2020;
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12. Liu W, Liu L, Kou G, Zheng Y, et al. Evaluation of nucleocapsid and spike protein-based ELISAs for detecting antibodies against SARS-CoV-2. medxriv [Internet]. 2020;
13. Zhang W, Du R, Li B, Zheng X, et al. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. Emerging microbes and infections. 2020; 9(1):386-389.
14. Zhou P, Yang XL, Wang X, Hu B, et al. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3.
15. Wang N, Li SY, Yang XL, et al. Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China. Virol Sin. 2018;33(1):104–107. doi:10.1007/s12250-018-0012-7
16. Che X, Qiu L, Liao Z, Wang Y, et al. Antigenic cross-reactivity between severe acute respiratory syndrome-associated coronavirus and human coronaviruses 229E and OC43. The Journal of Infectious Diseases, Volume 191, Issue 12, 15 June 2005, Pages 2033–2037, https://doi.org/10.1086/430355
17. https://www.who.int/news-room/commentaries/detail/advice-on-the-use-of-point-of-care-immunodiagnostic-tests-for-covid-19
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